| 2022-04-15 | Leyton OrientvScunthorpeLeague Two · England | 3–0 | League Two · England |
| 2022-04-09 | SuttonvLeyton OrientLeague Two · England | 1–0 | League Two · England |
| 2022-04-02 | WalsallvLeyton OrientLeague Two · England | 0–2 | League Two · England |
| 2022-03-29 | OldhamvLeyton OrientLeague Two · England | 2–0 | League Two · England |
| 2022-03-26 | Leyton OrientvBarrowLeague Two · England | 2–0 | League Two · England |
| 2022-03-22 | HarrogatevLeyton OrientLeague Two · England | 0–3 | League Two · England |
| 2022-03-19 | Leyton OrientvRochdaleLeague Two · England | 3–1 | League Two · England |
| 2022-03-15 | Forest GreenvLeyton OrientLeague Two · England | 1–1 | League Two · England |
| 2022-03-12 | HartlepoolvLeyton OrientLeague Two · England | 0–0 | League Two · England |
| 2022-03-05 | Leyton OrientvStevenageLeague Two · England | 2–2 | League Two · England |
| 2022-03-01 | ColchestervLeyton OrientLeague Two · England | 2–2 | League Two · England |
| 2022-02-26 | Leyton OrientvCarlisleLeague Two · England | 0–1 | League Two · England |
| 2022-02-22 | Leyton OrientvBristol RvsLeague Two · England | 0–2 | League Two · England |
| 2022-02-12 | Leyton OrientvSalfordLeague Two · England | 0–2 | League Two · England |
| 2022-02-08 | ExetervLeyton OrientLeague Two · England | 1–0 | League Two · England |
| 2022-02-05 | Leyton OrientvColchesterLeague Two · England | 0–1 | League Two · England |
| 2022-02-01 | BradfordvLeyton OrientLeague Two · England | 1–1 | League Two · England |
| 2022-01-29 | MansfieldvLeyton OrientLeague Two · England | 2–0 | League Two · England |
| 2022-01-25 | Leyton OrientvNewport CountyLeague Two · England | 0–1 | League Two · England |
| 2022-01-22 | Leyton OrientvPort ValeLeague Two · England | 0–0 | League Two · England |
| 2021-12-18 | TranmerevLeyton OrientLeague Two · England | 1–0 | League Two · England |
| 2021-12-11 | Leyton OrientvCrawley TownLeague Two · England | 1–2 | League Two · England |
| 2021-12-07 | Leyton OrientvSwindonLeague Two · England | 4–1 | League Two · England |
| 2021-11-27 | NorthamptonvLeyton OrientLeague Two · England | 1–0 | League Two · England |
| 2021-11-23 | ScunthorpevLeyton OrientLeague Two · England | 1–1 | League Two · England |
| 2021-11-20 | Leyton OrientvSuttonLeague Two · England | 4–1 | League Two · England |
| 2021-11-13 | RochdalevLeyton OrientLeague Two · England | 2–2 | League Two · England |
| 2021-10-30 | Leyton OrientvHartlepoolLeague Two · England | 5–0 | League Two · England |
| 2021-10-23 | StevenagevLeyton OrientLeague Two · England | 0–0 | League Two · England |
| 2021-10-19 | Leyton OrientvForest GreenLeague Two · England | 1–1 | League Two · England |
| 2021-10-16 | Leyton OrientvWalsallLeague Two · England | 0–0 | League Two · England |
| 2021-10-09 | BarrowvLeyton OrientLeague Two · England | 1–1 | League Two · England |
| 2021-10-02 | Port ValevLeyton OrientLeague Two · England | 3–2 | League Two · England |
| 2021-09-25 | Leyton OrientvMansfieldLeague Two · England | 0–0 | League Two · England |
| 2021-09-18 | Bristol RvsvLeyton OrientLeague Two · England | 1–3 | League Two · England |
| 2021-09-11 | Leyton OrientvOldhamLeague Two · England | 4–0 | League Two · England |
| 2021-09-04 | Newport CountyvLeyton OrientLeague Two · England | 2–2 | League Two · England |
| 2021-08-28 | Leyton OrientvBradfordLeague Two · England | 2–0 | League Two · England |
| 2021-08-24 | Leyton OrientvHarrogateLeague Two · England | 0–2 | League Two · England |
| 2021-08-21 | CarlislevLeyton OrientLeague Two · England | 1–1 | League Two · England |
| 2021-08-14 | Leyton OrientvExeterLeague Two · England | 3–0 | League Two · England |
| 2021-08-07 | SalfordvLeyton OrientLeague Two · England | 1–1 | League Two · England |
| 2021-05-08 | SalfordvLeyton OrientLeague Two · England | 3–0 | League Two · England |
| 2021-05-01 | Leyton OrientvCarlisleLeague Two · England | 2–3 | League Two · England |
| 2021-04-24 | SouthendvLeyton OrientLeague Two · England | 2–1 | League Two · England |
| 2021-04-20 | Leyton OrientvCambridgeLeague Two · England | 2–4 | League Two · England |
| 2021-04-17 | Leyton OrientvBarrowLeague Two · England | 2–0 | League Two · England |
| 2021-04-13 | HarrogatevLeyton OrientLeague Two · England | 2–2 | League Two · England |
| 2021-04-10 | CheltenhamvLeyton OrientLeague Two · England | 1–0 | League Two · England |
| 2021-04-05 | Leyton OrientvWalsallLeague Two · England | 0–0 | League Two · England |