| 2022-12-29 | PlymouthvWycombeLeague One · England | 1–0 | League One · England |
| 2022-12-26 | CheltenhamvPlymouthLeague One · England | 0–1 | League One · England |
| 2022-12-17 | PlymouthvMorecambeLeague One · England | 2–1 | League One · England |
| 2022-12-10 | CambridgevPlymouthLeague One · England | 0–0 | League One · England |
| 2022-12-02 | PlymouthvPort ValeLeague One · England | 0–2 | League One · England |
| 2022-11-19 | BurtonvPlymouthLeague One · England | 2–2 | League One · England |
| 2022-11-12 | LincolnvPlymouthLeague One · England | 1–1 | League One · England |
| 2022-10-31 | PlymouthvExeterLeague One · England | 4–2 | League One · England |
| 2022-10-25 | PlymouthvShrewsburyLeague One · England | 2–1 | League One · England |
| 2022-10-22 | Bristol RvsvPlymouthLeague One · England | 2–2 | League One · England |
| 2022-10-15 | Milton Keynes DonsvPlymouthLeague One · England | 1–4 | League One · England |
| 2022-10-08 | PlymouthvAccringtonLeague One · England | 3–0 | League One · England |
| 2022-10-04 | PlymouthvSheffield WedsLeague One · England | 2–1 | League One · England |
| 2022-10-01 | WycombevPlymouthLeague One · England | 0–1 | League One · England |
| 2022-09-25 | PlymouthvIpswichLeague One · England | 2–1 | League One · England |
| 2022-09-17 | PortsmouthvPlymouthLeague One · England | 2–2 | League One · England |
| 2022-09-13 | PlymouthvOxfordLeague One · England | 1–0 | League One · England |
| 2022-09-03 | DerbyvPlymouthLeague One · England | 2–3 | League One · England |
| 2022-08-27 | PlymouthvBoltonLeague One · England | 2–0 | League One · England |
| 2022-08-20 | Forest GreenvPlymouthLeague One · England | 0–3 | League One · England |
| 2022-08-16 | CharltonvPlymouthLeague One · England | 5–1 | League One · England |
| 2022-08-13 | PlymouthvPeterboroLeague One · England | 2–0 | League One · England |
| 2022-08-06 | Fleetwood TownvPlymouthLeague One · England | 2–1 | League One · England |
| 2022-07-30 | PlymouthvBarnsleyLeague One · England | 1–0 | League One · England |
| 2022-04-30 | PlymouthvMilton Keynes DonsLeague One · England | 0–5 | League One · England |
| 2022-04-23 | WiganvPlymouthLeague One · England | 1–1 | League One · England |
| 2022-04-18 | PlymouthvSunderlandLeague One · England | 0–0 | League One · England |
| 2022-04-15 | WycombevPlymouthLeague One · England | 2–0 | League One · England |
| 2022-04-09 | BurtonvPlymouthLeague One · England | 0–0 | League One · England |
| 2022-04-02 | PlymouthvOxfordLeague One · England | 1–0 | League One · England |
| 2022-03-26 | IpswichvPlymouthLeague One · England | 1–0 | League One · England |
| 2022-03-22 | PlymouthvCheltenhamLeague One · England | 2–0 | League One · England |
| 2022-03-19 | PlymouthvAccringtonLeague One · England | 4–0 | League One · England |
| 2022-03-15 | PlymouthvPortsmouthLeague One · England | 1–0 | League One · England |
| 2022-03-12 | BoltonvPlymouthLeague One · England | 0–1 | League One · England |
| 2022-03-08 | PlymouthvAFC WimbledonLeague One · England | 2–0 | League One · England |
| 2022-03-05 | PlymouthvMorecambeLeague One · England | 2–0 | League One · England |
| 2022-02-26 | PlymouthvRotherhamLeague One · England | 0–1 | League One · England |
| 2022-02-22 | CambridgevPlymouthLeague One · England | 2–0 | League One · England |
| 2022-02-19 | GillinghamvPlymouthLeague One · England | 0–2 | League One · England |
| 2022-02-12 | PlymouthvShrewsburyLeague One · England | 1–0 | League One · England |
| 2022-02-08 | CrewevPlymouthLeague One · England | 1–4 | League One · England |
| 2022-01-29 | DoncastervPlymouthLeague One · England | 1–3 | League One · England |
| 2022-01-25 | Fleetwood TownvPlymouthLeague One · England | 3–3 | League One · England |
| 2022-01-22 | PlymouthvLincolnLeague One · England | 1–2 | League One · England |
| 2022-01-15 | Sheffield WedsvPlymouthLeague One · England | 4–2 | League One · England |