| 2022-12-29 | PeterborovMilton Keynes DonsLeague One · England | 2–0 | League One · England |
| 2022-12-26 | Milton Keynes DonsvForest GreenLeague One · England | 1–0 | League One · England |
| 2022-12-17 | PortsmouthvMilton Keynes DonsLeague One · England | 0–2 | League One · England |
| 2022-12-10 | Milton Keynes DonsvFleetwood TownLeague One · England | 1–2 | League One · England |
| 2022-12-03 | Milton Keynes DonsvBurtonLeague One · England | 1–1 | League One · England |
| 2022-11-19 | BarnsleyvMilton Keynes DonsLeague One · England | 3–1 | League One · England |
| 2022-11-12 | Milton Keynes DonsvDerbyLeague One · England | 1–3 | League One · England |
| 2022-10-29 | CheltenhamvMilton Keynes DonsLeague One · England | 0–0 | League One · England |
| 2022-10-25 | CharltonvMilton Keynes DonsLeague One · England | 0–2 | League One · England |
| 2022-10-22 | Milton Keynes DonsvWycombeLeague One · England | 0–1 | League One · England |
| 2022-10-15 | Milton Keynes DonsvPlymouthLeague One · England | 1–4 | League One · England |
| 2022-10-11 | Milton Keynes DonsvBristol RvsLeague One · England | 0–1 | League One · England |
| 2022-10-08 | ShrewsburyvMilton Keynes DonsLeague One · England | 2–1 | League One · England |
| 2022-10-01 | Milton Keynes DonsvPeterboroLeague One · England | 2–3 | League One · England |
| 2022-09-17 | OxfordvMilton Keynes DonsLeague One · England | 1–2 | League One · England |
| 2022-09-13 | Milton Keynes DonsvBoltonLeague One · England | 0–2 | League One · England |
| 2022-09-03 | ExetervMilton Keynes DonsLeague One · England | 1–0 | League One · England |
| 2022-08-27 | MorecambevMilton Keynes DonsLeague One · England | 0–4 | League One · England |
| 2022-08-20 | Milton Keynes DonsvAccringtonLeague One · England | 1–1 | League One · England |
| 2022-08-16 | Milton Keynes DonsvPort ValeLeague One · England | 2–1 | League One · England |
| 2022-08-13 | IpswichvMilton Keynes DonsLeague One · England | 3–0 | League One · England |
| 2022-08-06 | Milton Keynes DonsvSheffield WedsLeague One · England | 0–1 | League One · England |
| 2022-07-30 | CambridgevMilton Keynes DonsLeague One · England | 1–0 | League One · England |
| 2022-04-30 | PlymouthvMilton Keynes DonsLeague One · England | 0–5 | League One · England |
| 2022-04-23 | Milton Keynes DonsvMorecambeLeague One · England | 2–0 | League One · England |
| 2022-04-19 | OxfordvMilton Keynes DonsLeague One · England | 1–0 | League One · England |
| 2022-04-16 | Milton Keynes DonsvSheffield WedsLeague One · England | 2–3 | League One · England |
| 2022-04-09 | AFC WimbledonvMilton Keynes DonsLeague One · England | 1–1 | League One · England |
| 2022-04-05 | Milton Keynes DonsvCreweLeague One · England | 2–1 | League One · England |
| 2022-04-02 | Milton Keynes DonsvShrewsburyLeague One · England | 2–0 | League One · England |
| 2022-03-19 | CambridgevMilton Keynes DonsLeague One · England | 0–1 | League One · England |
| 2022-03-12 | Milton Keynes DonsvWiganLeague One · England | 1–1 | League One · England |
| 2022-03-08 | Milton Keynes DonsvCheltenhamLeague One · England | 3–1 | League One · England |
| 2022-03-05 | RotherhamvMilton Keynes DonsLeague One · England | 1–2 | League One · England |
| 2022-02-26 | Milton Keynes DonsvBoltonLeague One · England | 2–0 | League One · England |
| 2022-02-22 | CharltonvMilton Keynes DonsLeague One · England | 0–2 | League One · England |
| 2022-02-19 | SunderlandvMilton Keynes DonsLeague One · England | 1–2 | League One · England |
| 2022-02-12 | Milton Keynes DonsvIpswichLeague One · England | 0–0 | League One · England |
| 2022-02-08 | Fleetwood TownvMilton Keynes DonsLeague One · England | 1–1 | League One · England |
| 2022-02-05 | Milton Keynes DonsvLincolnLeague One · England | 2–1 | League One · England |
| 2022-01-29 | WycombevMilton Keynes DonsLeague One · England | 0–1 | League One · England |
| 2022-01-25 | BurtonvMilton Keynes DonsLeague One · England | 0–1 | League One · England |
| 2022-01-22 | Milton Keynes DonsvDoncasterLeague One · England | 0–1 | League One · England |
| 2022-01-15 | PortsmouthvMilton Keynes DonsLeague One · England | 1–2 | League One · England |
| 2022-01-11 | Milton Keynes DonsvAFC WimbledonLeague One · England | 1–0 | League One · England |
| 2022-01-08 | AccringtonvMilton Keynes DonsLeague One · England | 1–1 | League One · England |
| 2022-01-01 | Milton Keynes DonsvGillinghamLeague One · England | 0–0 | League One · England |