| 2021-12-26 | LincolnvMilton Keynes DonsLeague One · England | 2–3 | League One · England |
| 2021-12-11 | Milton Keynes DonsvOxfordLeague One · England | 1–2 | League One · England |
| 2021-12-08 | Milton Keynes DonsvPlymouthLeague One · England | 1–1 | League One · England |
| 2021-11-27 | MorecambevMilton Keynes DonsLeague One · England | 0–4 | League One · England |
| 2021-11-23 | Sheffield WedsvMilton Keynes DonsLeague One · England | 2–1 | League One · England |
| 2021-11-20 | Milton Keynes DonsvBurtonLeague One · England | 1–0 | League One · England |
| 2021-11-13 | Milton Keynes DonsvCambridgeLeague One · England | 4–1 | League One · England |
| 2021-10-30 | CrewevMilton Keynes DonsLeague One · England | 1–4 | League One · England |
| 2021-10-23 | Milton Keynes DonsvRotherhamLeague One · England | 0–3 | League One · England |
| 2021-10-19 | WiganvMilton Keynes DonsLeague One · England | 1–2 | League One · England |
| 2021-10-16 | ShrewsburyvMilton Keynes DonsLeague One · England | 1–0 | League One · England |
| 2021-10-02 | DoncastervMilton Keynes DonsLeague One · England | 2–1 | League One · England |
| 2021-09-28 | Milton Keynes DonsvFleetwood TownLeague One · England | 3–3 | League One · England |
| 2021-09-25 | Milton Keynes DonsvWycombeLeague One · England | 1–0 | League One · England |
| 2021-09-18 | GillinghamvMilton Keynes DonsLeague One · England | 1–4 | League One · England |
| 2021-09-11 | Milton Keynes DonsvPortsmouthLeague One · England | 1–0 | League One · England |
| 2021-09-04 | CheltenhamvMilton Keynes DonsLeague One · England | 1–1 | League One · England |
| 2021-08-28 | Milton Keynes DonsvAccringtonLeague One · England | 2–0 | League One · England |
| 2021-08-21 | IpswichvMilton Keynes DonsLeague One · England | 2–2 | League One · England |
| 2021-08-17 | Milton Keynes DonsvCharltonLeague One · England | 2–1 | League One · England |
| 2021-08-14 | Milton Keynes DonsvSunderlandLeague One · England | 1–2 | League One · England |
| 2021-08-07 | BoltonvMilton Keynes DonsLeague One · England | 3–3 | League One · England |
| 2021-05-09 | Milton Keynes DonsvRochdaleLeague One · England | 0–3 | League One · England |
| 2021-05-01 | Fleetwood TownvMilton Keynes DonsLeague One · England | 1–1 | League One · England |
| 2021-04-24 | Milton Keynes DonsvSwindonLeague One · England | 5–0 | League One · England |
| 2021-04-20 | Bristol RvsvMilton Keynes DonsLeague One · England | 0–2 | League One · England |
| 2021-04-17 | Milton Keynes DonsvPortsmouthLeague One · England | 1–0 | League One · England |
| 2021-04-13 | LincolnvMilton Keynes DonsLeague One · England | 4–0 | League One · England |
| 2021-04-10 | IpswichvMilton Keynes DonsLeague One · England | 0–0 | League One · England |
| 2021-04-05 | Milton Keynes DonsvCreweLeague One · England | 0–2 | League One · England |
| 2021-03-27 | Milton Keynes DonsvDoncasterLeague One · England | 1–0 | League One · England |
| 2021-03-20 | BurtonvMilton Keynes DonsLeague One · England | 1–2 | League One · England |
| 2021-03-16 | Milton Keynes DonsvPlymouthLeague One · England | 2–1 | League One · England |
| 2021-03-13 | Milton Keynes DonsvAccringtonLeague One · England | 3–2 | League One · England |
| 2021-03-09 | Milton Keynes DonsvBlackpoolLeague One · England | 0–1 | League One · England |
| 2021-03-06 | WiganvMilton Keynes DonsLeague One · England | 3–0 | League One · England |
| 2021-03-02 | GillinghamvMilton Keynes DonsLeague One · England | 3–2 | League One · England |
| 2021-02-27 | Milton Keynes DonsvOxfordLeague One · England | 1–1 | League One · England |
| 2021-02-23 | ShrewsburyvMilton Keynes DonsLeague One · England | 4–2 | League One · England |
| 2021-02-20 | Milton Keynes DonsvNorthamptonLeague One · England | 4–3 | League One · England |
| 2021-02-13 | HullvMilton Keynes DonsLeague One · England | 0–1 | League One · England |
| 2021-02-09 | RochdalevMilton Keynes DonsLeague One · England | 1–4 | League One · England |
| 2021-02-06 | Milton Keynes DonsvSunderlandLeague One · England | 2–2 | League One · England |
| 2021-01-30 | AFC WimbledonvMilton Keynes DonsLeague One · England | 0–2 | League One · England |
| 2021-01-26 | Milton Keynes DonsvCharltonLeague One · England | 0–1 | League One · England |
| 2021-01-19 | Milton Keynes DonsvFleetwood TownLeague One · England | 3–1 | League One · England |
| 2021-01-16 | PeterborovMilton Keynes DonsLeague One · England | 3–0 | League One · England |