| 2021-12-18 | CambridgevRotherhamLeague One · England | 0–1 | League One · England |
| 2021-12-11 | CharltonvCambridgeLeague One · England | 2–0 | League One · England |
| 2021-12-07 | CheltenhamvCambridgeLeague One · England | 0–5 | League One · England |
| 2021-11-27 | CambridgevSunderlandLeague One · England | 1–2 | League One · England |
| 2021-11-23 | CambridgevWiganLeague One · England | 2–2 | League One · England |
| 2021-11-20 | RotherhamvCambridgeLeague One · England | 3–1 | League One · England |
| 2021-11-13 | Milton Keynes DonsvCambridgeLeague One · England | 4–1 | League One · England |
| 2021-11-02 | MorecambevCambridgeLeague One · England | 0–2 | League One · England |
| 2021-10-30 | CambridgevAFC WimbledonLeague One · England | 1–0 | League One · England |
| 2021-10-26 | DoncastervCambridgeLeague One · England | 1–1 | League One · England |
| 2021-10-23 | ShrewsburyvCambridgeLeague One · England | 4–1 | League One · England |
| 2021-10-19 | CambridgevSheffield WedsLeague One · England | 1–1 | League One · England |
| 2021-10-16 | CambridgevIpswichLeague One · England | 2–2 | League One · England |
| 2021-10-02 | CrewevCambridgeLeague One · England | 2–2 | League One · England |
| 2021-09-28 | CambridgevGillinghamLeague One · England | 0–2 | League One · England |
| 2021-09-25 | CambridgevFleetwood TownLeague One · England | 2–2 | League One · England |
| 2021-09-18 | PortsmouthvCambridgeLeague One · England | 1–2 | League One · England |
| 2021-09-11 | CambridgevLincolnLeague One · England | 1–5 | League One · England |
| 2021-08-28 | CambridgevBoltonLeague One · England | 1–0 | League One · England |
| 2021-08-21 | CambridgevBurtonLeague One · England | 3–0 | League One · England |
| 2021-08-17 | PlymouthvCambridgeLeague One · England | 1–1 | League One · England |
| 2021-08-14 | AccringtonvCambridgeLeague One · England | 2–1 | League One · England |
| 2021-08-07 | CambridgevOxfordLeague One · England | 1–1 | League One · England |