| 2025-12-29 | BirminghamvSouthamptonChampionship · England | 1–1 | Championship · England |
| 2025-12-26 | OxfordvSouthamptonChampionship · England | 2–1 | Championship · England |
| 2025-12-20 | SouthamptonvCoventryChampionship · England | 1–1 | Championship · England |
| 2025-12-13 | NorwichvSouthamptonChampionship · England | 2–1 | Championship · England |
| 2025-12-09 | SouthamptonvWest BromChampionship · England | 3–2 | Championship · England |
| 2025-12-06 | SouthamptonvBirminghamChampionship · England | 3–1 | Championship · England |
| 2025-11-29 | MillwallvSouthamptonChampionship · England | 3–2 | Championship · England |
| 2025-11-25 | SouthamptonvLeicesterChampionship · England | 3–0 | Championship · England |
| 2025-11-22 | CharltonvSouthamptonChampionship · England | 1–5 | Championship · England |
| 2025-11-08 | SouthamptonvSheffield WedsChampionship · England | 3–1 | Championship · England |
| 2025-11-05 | QPRvSouthamptonChampionship · England | 1–2 | Championship · England |
| 2025-11-01 | SouthamptonvPrestonChampionship · England | 0–2 | Championship · England |
| 2025-10-25 | BlackburnvSouthamptonChampionship · England | 2–1 | Championship · England |
| 2025-10-21 | Bristol CityvSouthamptonChampionship · England | 3–1 | Championship · England |
| 2025-10-18 | SouthamptonvSwanseaChampionship · England | 0–0 | Championship · England |
| 2025-10-04 | DerbyvSouthamptonChampionship · England | 1–1 | Championship · England |
| 2025-09-30 | Sheffield UnitedvSouthamptonChampionship · England | 1–2 | Championship · England |
| 2025-09-27 | SouthamptonvMiddlesbroughChampionship · England | 1–1 | Championship · England |
| 2025-09-20 | HullvSouthamptonChampionship · England | 3–1 | Championship · England |
| 2025-09-14 | SouthamptonvPortsmouthChampionship · England | 0–0 | Championship · England |
| 2025-08-30 | WatfordvSouthamptonChampionship · England | 2–2 | Championship · England |
| 2025-08-23 | SouthamptonvStokeChampionship · England | 1–2 | Championship · England |
| 2025-08-17 | IpswichvSouthamptonChampionship · England | 1–1 | Championship · England |
| 2025-08-09 | SouthamptonvWrexhamChampionship · England | 2–1 | Championship · England |