| 2021-12-19 | WolvesvChelseaPremier League · England | 0–0 | Premier League · England |
| 2021-12-15 | BrightonvWolvesPremier League · England | 0–1 | Premier League · England |
| 2021-12-11 | Man CityvWolvesPremier League · England | 1–0 | Premier League · England |
| 2021-12-04 | WolvesvLiverpoolPremier League · England | 0–1 | Premier League · England |
| 2021-12-01 | WolvesvBurnleyPremier League · England | 0–0 | Premier League · England |
| 2021-11-27 | NorwichvWolvesPremier League · England | 0–0 | Premier League · England |
| 2021-11-20 | WolvesvWest HamPremier League · England | 1–0 | Premier League · England |
| 2021-11-06 | Crystal PalacevWolvesPremier League · England | 2–0 | Premier League · England |
| 2021-11-01 | WolvesvEvertonPremier League · England | 2–1 | Premier League · England |
| 2021-10-23 | LeedsvWolvesPremier League · England | 1–1 | Premier League · England |
| 2021-10-16 | Aston VillavWolvesPremier League · England | 2–3 | Premier League · England |
| 2021-10-02 | WolvesvNewcastlePremier League · England | 2–1 | Premier League · England |
| 2021-09-26 | SouthamptonvWolvesPremier League · England | 0–1 | Premier League · England |
| 2021-09-18 | WolvesvBrentfordPremier League · England | 0–2 | Premier League · England |
| 2021-09-11 | WatfordvWolvesPremier League · England | 0–2 | Premier League · England |
| 2021-08-29 | WolvesvMan UnitedPremier League · England | 0–1 | Premier League · England |
| 2021-08-22 | WolvesvTottenhamPremier League · England | 0–1 | Premier League · England |
| 2021-08-14 | LeicestervWolvesPremier League · England | 1–0 | Premier League · England |
| 2021-05-23 | WolvesvMan UnitedPremier League · England | 1–2 | Premier League · England |
| 2021-05-19 | EvertonvWolvesPremier League · England | 1–0 | Premier League · England |
| 2021-05-16 | TottenhamvWolvesPremier League · England | 2–0 | Premier League · England |
| 2021-05-09 | WolvesvBrightonPremier League · England | 2–1 | Premier League · England |
| 2021-05-03 | West BromvWolvesPremier League · England | 1–1 | Premier League · England |
| 2021-04-25 | WolvesvBurnleyPremier League · England | 0–4 | Premier League · England |
| 2021-04-17 | WolvesvSheffield UnitedPremier League · England | 1–0 | Premier League · England |
| 2021-04-09 | FulhamvWolvesPremier League · England | 0–1 | Premier League · England |
| 2021-04-05 | WolvesvWest HamPremier League · England | 2–3 | Premier League · England |
| 2021-03-15 | WolvesvLiverpoolPremier League · England | 0–1 | Premier League · England |
| 2021-03-06 | Aston VillavWolvesPremier League · England | 0–0 | Premier League · England |
| 2021-03-02 | Man CityvWolvesPremier League · England | 4–1 | Premier League · England |
| 2021-02-27 | NewcastlevWolvesPremier League · England | 1–1 | Premier League · England |
| 2021-02-19 | WolvesvLeedsPremier League · England | 1–0 | Premier League · England |
| 2021-02-14 | SouthamptonvWolvesPremier League · England | 1–2 | Premier League · England |
| 2021-02-07 | WolvesvLeicesterPremier League · England | 0–0 | Premier League · England |
| 2021-02-02 | WolvesvArsenalPremier League · England | 2–1 | Premier League · England |
| 2021-01-30 | Crystal PalacevWolvesPremier League · England | 1–0 | Premier League · England |
| 2021-01-27 | ChelseavWolvesPremier League · England | 0–0 | Premier League · England |
| 2021-01-16 | WolvesvWest BromPremier League · England | 2–3 | Premier League · England |
| 2021-01-12 | WolvesvEvertonPremier League · England | 1–2 | Premier League · England |
| 2021-01-02 | BrightonvWolvesPremier League · England | 3–3 | Premier League · England |