| 2021-12-27 | NewcastlevMan UnitedPremier League · England | 1–1 | Premier League · England |
| 2021-12-19 | NewcastlevMan CityPremier League · England | 0–4 | Premier League · England |
| 2021-12-16 | LiverpoolvNewcastlePremier League · England | 3–1 | Premier League · England |
| 2021-12-12 | LeicestervNewcastlePremier League · England | 4–0 | Premier League · England |
| 2021-12-04 | NewcastlevBurnleyPremier League · England | 1–0 | Premier League · England |
| 2021-11-30 | NewcastlevNorwichPremier League · England | 1–1 | Premier League · England |
| 2021-11-27 | ArsenalvNewcastlePremier League · England | 2–0 | Premier League · England |
| 2021-11-20 | NewcastlevBrentfordPremier League · England | 3–3 | Premier League · England |
| 2021-11-06 | BrightonvNewcastlePremier League · England | 1–1 | Premier League · England |
| 2021-10-30 | NewcastlevChelseaPremier League · England | 0–3 | Premier League · England |
| 2021-10-23 | Crystal PalacevNewcastlePremier League · England | 1–1 | Premier League · England |
| 2021-10-17 | NewcastlevTottenhamPremier League · England | 2–3 | Premier League · England |
| 2021-10-02 | WolvesvNewcastlePremier League · England | 2–1 | Premier League · England |
| 2021-09-25 | WatfordvNewcastlePremier League · England | 1–1 | Premier League · England |
| 2021-09-17 | NewcastlevLeedsPremier League · England | 1–1 | Premier League · England |
| 2021-09-11 | Man UnitedvNewcastlePremier League · England | 4–1 | Premier League · England |
| 2021-08-28 | NewcastlevSouthamptonPremier League · England | 2–2 | Premier League · England |
| 2021-08-21 | Aston VillavNewcastlePremier League · England | 2–0 | Premier League · England |
| 2021-08-15 | NewcastlevWest HamPremier League · England | 2–4 | Premier League · England |
| 2021-05-23 | FulhamvNewcastlePremier League · England | 0–2 | Premier League · England |
| 2021-05-19 | NewcastlevSheffield UnitedPremier League · England | 1–0 | Premier League · England |
| 2021-05-14 | NewcastlevMan CityPremier League · England | 3–4 | Premier League · England |
| 2021-05-07 | LeicestervNewcastlePremier League · England | 2–4 | Premier League · England |
| 2021-05-02 | NewcastlevArsenalPremier League · England | 0–2 | Premier League · England |
| 2021-04-24 | LiverpoolvNewcastlePremier League · England | 1–1 | Premier League · England |
| 2021-04-17 | NewcastlevWest HamPremier League · England | 3–2 | Premier League · England |
| 2021-04-11 | BurnleyvNewcastlePremier League · England | 1–2 | Premier League · England |
| 2021-04-04 | NewcastlevTottenhamPremier League · England | 2–2 | Premier League · England |
| 2021-03-20 | BrightonvNewcastlePremier League · England | 3–0 | Premier League · England |
| 2021-03-12 | NewcastlevAston VillaPremier League · England | 1–1 | Premier League · England |
| 2021-03-07 | West BromvNewcastlePremier League · England | 0–0 | Premier League · England |
| 2021-02-27 | NewcastlevWolvesPremier League · England | 1–1 | Premier League · England |
| 2021-02-21 | Man UnitedvNewcastlePremier League · England | 3–1 | Premier League · England |
| 2021-02-15 | ChelseavNewcastlePremier League · England | 2–0 | Premier League · England |
| 2021-02-06 | NewcastlevSouthamptonPremier League · England | 3–2 | Premier League · England |
| 2021-02-02 | NewcastlevCrystal PalacePremier League · England | 1–2 | Premier League · England |
| 2021-01-30 | EvertonvNewcastlePremier League · England | 0–2 | Premier League · England |
| 2021-01-26 | NewcastlevLeedsPremier League · England | 1–2 | Premier League · England |
| 2021-01-23 | Aston VillavNewcastlePremier League · England | 2–0 | Premier League · England |
| 2021-01-18 | ArsenalvNewcastlePremier League · England | 3–0 | Premier League · England |
| 2021-01-12 | Sheffield UnitedvNewcastlePremier League · England | 1–0 | Premier League · England |
| 2021-01-03 | NewcastlevLeicesterPremier League · England | 1–2 | Premier League · England |