| 2021-12-29 | BrentfordvMan CityPremier League · England | 0–1 | Premier League · England |
| 2021-12-26 | Man CityvLeicesterPremier League · England | 6–3 | Premier League · England |
| 2021-12-19 | NewcastlevMan CityPremier League · England | 0–4 | Premier League · England |
| 2021-12-14 | Man CityvLeedsPremier League · England | 7–0 | Premier League · England |
| 2021-12-11 | Man CityvWolvesPremier League · England | 1–0 | Premier League · England |
| 2021-12-04 | WatfordvMan CityPremier League · England | 1–3 | Premier League · England |
| 2021-12-01 | Aston VillavMan CityPremier League · England | 1–2 | Premier League · England |
| 2021-11-28 | Man CityvWest HamPremier League · England | 2–1 | Premier League · England |
| 2021-11-21 | Man CityvEvertonPremier League · England | 3–0 | Premier League · England |
| 2021-11-06 | Man UnitedvMan CityPremier League · England | 0–2 | Premier League · England |
| 2021-10-30 | Man CityvCrystal PalacePremier League · England | 0–2 | Premier League · England |
| 2021-10-23 | BrightonvMan CityPremier League · England | 1–4 | Premier League · England |
| 2021-10-16 | Man CityvBurnleyPremier League · England | 2–0 | Premier League · England |
| 2021-10-03 | LiverpoolvMan CityPremier League · England | 2–2 | Premier League · England |
| 2021-09-25 | ChelseavMan CityPremier League · England | 0–1 | Premier League · England |
| 2021-09-18 | Man CityvSouthamptonPremier League · England | 0–0 | Premier League · England |
| 2021-09-11 | LeicestervMan CityPremier League · England | 0–1 | Premier League · England |
| 2021-08-28 | Man CityvArsenalPremier League · England | 5–0 | Premier League · England |
| 2021-08-21 | Man CityvNorwichPremier League · England | 5–0 | Premier League · England |
| 2021-08-15 | TottenhamvMan CityPremier League · England | 1–0 | Premier League · England |
| 2021-05-23 | Man CityvEvertonPremier League · England | 5–0 | Premier League · England |
| 2021-05-18 | BrightonvMan CityPremier League · England | 3–2 | Premier League · England |
| 2021-05-14 | NewcastlevMan CityPremier League · England | 3–4 | Premier League · England |
| 2021-05-08 | Man CityvChelseaPremier League · England | 1–2 | Premier League · England |
| 2021-05-01 | Crystal PalacevMan CityPremier League · England | 0–2 | Premier League · England |
| 2021-04-21 | Aston VillavMan CityPremier League · England | 1–2 | Premier League · England |
| 2021-04-10 | Man CityvLeedsPremier League · England | 1–2 | Premier League · England |
| 2021-04-03 | LeicestervMan CityPremier League · England | 0–2 | Premier League · England |
| 2021-03-13 | FulhamvMan CityPremier League · England | 0–3 | Premier League · England |
| 2021-03-10 | Man CityvSouthamptonPremier League · England | 5–2 | Premier League · England |
| 2021-03-07 | Man CityvMan UnitedPremier League · England | 0–2 | Premier League · England |
| 2021-03-02 | Man CityvWolvesPremier League · England | 4–1 | Premier League · England |
| 2021-02-27 | Man CityvWest HamPremier League · England | 2–1 | Premier League · England |
| 2021-02-21 | ArsenalvMan CityPremier League · England | 0–1 | Premier League · England |
| 2021-02-17 | EvertonvMan CityPremier League · England | 1–3 | Premier League · England |
| 2021-02-13 | Man CityvTottenhamPremier League · England | 3–0 | Premier League · England |
| 2021-02-07 | LiverpoolvMan CityPremier League · England | 1–4 | Premier League · England |
| 2021-02-03 | BurnleyvMan CityPremier League · England | 0–2 | Premier League · England |
| 2021-01-30 | Man CityvSheffield UnitedPremier League · England | 1–0 | Premier League · England |
| 2021-01-26 | West BromvMan CityPremier League · England | 0–5 | Premier League · England |
| 2021-01-20 | Man CityvAston VillaPremier League · England | 2–0 | Premier League · England |
| 2021-01-17 | Man CityvCrystal PalacePremier League · England | 4–0 | Premier League · England |
| 2021-01-13 | Man CityvBrightonPremier League · England | 1–0 | Premier League · England |
| 2021-01-03 | ChelseavMan CityPremier League · England | 1–3 | Premier League · England |