| 2016-09-10 | ArsenalvSouthamptonPremier League · England | 2–1 | Premier League · England |
| 2016-08-27 | SouthamptonvSunderlandPremier League · England | 1–1 | Premier League · England |
| 2016-08-19 | Man UnitedvSouthamptonPremier League · England | 2–0 | Premier League · England |
| 2016-08-13 | SouthamptonvWatfordPremier League · England | 1–1 | Premier League · England |
| 2016-05-15 | SouthamptonvCrystal PalacePremier League · England | 4–1 | Premier League · England |
| 2016-05-08 | TottenhamvSouthamptonPremier League · England | 1–2 | Premier League · England |
| 2016-05-01 | SouthamptonvMan CityPremier League · England | 4–2 | Premier League · England |
| 2016-04-23 | Aston VillavSouthamptonPremier League · England | 2–4 | Premier League · England |
| 2016-04-16 | EvertonvSouthamptonPremier League · England | 1–1 | Premier League · England |
| 2016-04-09 | SouthamptonvNewcastlePremier League · England | 3–1 | Premier League · England |
| 2016-04-03 | LeicestervSouthamptonPremier League · England | 1–0 | Premier League · England |
| 2016-03-20 | SouthamptonvLiverpoolPremier League · England | 3–2 | Premier League · England |
| 2016-03-12 | StokevSouthamptonPremier League · England | 1–2 | Premier League · England |
| 2016-03-05 | SouthamptonvSunderlandPremier League · England | 1–1 | Premier League · England |
| 2016-03-01 | BournemouthvSouthamptonPremier League · England | 2–0 | Premier League · England |
| 2016-02-27 | SouthamptonvChelseaPremier League · England | 1–2 | Premier League · England |
| 2016-02-13 | SwanseavSouthamptonPremier League · England | 0–1 | Premier League · England |
| 2016-02-06 | SouthamptonvWest HamPremier League · England | 1–0 | Premier League · England |
| 2016-02-02 | ArsenalvSouthamptonPremier League · England | 0–0 | Premier League · England |
| 2016-01-23 | Man UnitedvSouthamptonPremier League · England | 0–1 | Premier League · England |
| 2016-01-16 | SouthamptonvWest BromPremier League · England | 3–0 | Premier League · England |
| 2016-01-13 | SouthamptonvWatfordPremier League · England | 2–0 | Premier League · England |
| 2016-01-02 | NorwichvSouthamptonPremier League · England | 1–0 | Premier League · England |
| 2015-12-28 | West HamvSouthamptonPremier League · England | 2–1 | Premier League · England |
| 2015-12-26 | SouthamptonvArsenalPremier League · England | 4–0 | Premier League · England |
| 2015-12-19 | SouthamptonvTottenhamPremier League · England | 0–2 | Premier League · England |
| 2015-12-12 | Crystal PalacevSouthamptonPremier League · England | 1–0 | Premier League · England |
| 2015-12-05 | SouthamptonvAston VillaPremier League · England | 1–1 | Premier League · England |
| 2015-11-28 | Man CityvSouthamptonPremier League · England | 3–1 | Premier League · England |
| 2015-11-21 | SouthamptonvStokePremier League · England | 0–1 | Premier League · England |
| 2015-11-07 | SunderlandvSouthamptonPremier League · England | 0–1 | Premier League · England |
| 2015-11-01 | SouthamptonvBournemouthPremier League · England | 2–0 | Premier League · England |
| 2015-10-25 | LiverpoolvSouthamptonPremier League · England | 1–1 | Premier League · England |
| 2015-10-17 | SouthamptonvLeicesterPremier League · England | 2–2 | Premier League · England |
| 2015-10-03 | ChelseavSouthamptonPremier League · England | 1–3 | Premier League · England |
| 2015-09-26 | SouthamptonvSwanseaPremier League · England | 3–1 | Premier League · England |
| 2015-09-20 | SouthamptonvMan UnitedPremier League · England | 2–3 | Premier League · England |
| 2015-09-12 | West BromvSouthamptonPremier League · England | 0–0 | Premier League · England |
| 2015-08-30 | SouthamptonvNorwichPremier League · England | 3–0 | Premier League · England |
| 2015-08-23 | WatfordvSouthamptonPremier League · England | 0–0 | Premier League · England |
| 2015-08-15 | SouthamptonvEvertonPremier League · England | 0–3 | Premier League · England |
| 2015-08-09 | NewcastlevSouthamptonPremier League · England | 2–2 | Premier League · England |
| 2015-05-24 | Man CityvSouthamptonPremier League · England | 2–0 | Premier League · England |
| 2015-05-16 | SouthamptonvAston VillaPremier League · England | 6–1 | Premier League · England |
| 2015-05-09 | LeicestervSouthamptonPremier League · England | 2–0 | Premier League · England |
| 2015-05-02 | SunderlandvSouthamptonPremier League · England | 2–1 | Premier League · England |
| 2015-04-25 | SouthamptonvTottenhamPremier League · England | 2–2 | Premier League · England |
| 2015-04-18 | StokevSouthamptonPremier League · England | 2–1 | Premier League · England |
| 2015-04-11 | SouthamptonvHullPremier League · England | 2–0 | Premier League · England |
| 2015-04-04 | EvertonvSouthamptonPremier League · England | 1–0 | Premier League · England |