| 2017-12-10 | SouthamptonvArsenalPremier League · England | 1–1 | Premier League · England |
| 2017-12-03 | BournemouthvSouthamptonPremier League · England | 1–1 | Premier League · England |
| 2017-11-29 | Man CityvSouthamptonPremier League · England | 2–1 | Premier League · England |
| 2017-11-26 | SouthamptonvEvertonPremier League · England | 4–1 | Premier League · England |
| 2017-11-18 | LiverpoolvSouthamptonPremier League · England | 3–0 | Premier League · England |
| 2017-11-04 | SouthamptonvBurnleyPremier League · England | 0–1 | Premier League · England |
| 2017-10-29 | BrightonvSouthamptonPremier League · England | 1–1 | Premier League · England |
| 2017-10-21 | SouthamptonvWest BromPremier League · England | 1–0 | Premier League · England |
| 2017-10-15 | SouthamptonvNewcastlePremier League · England | 2–2 | Premier League · England |
| 2017-09-30 | StokevSouthamptonPremier League · England | 2–1 | Premier League · England |
| 2017-09-23 | SouthamptonvMan UnitedPremier League · England | 0–1 | Premier League · England |
| 2017-09-16 | Crystal PalacevSouthamptonPremier League · England | 0–1 | Premier League · England |
| 2017-09-09 | SouthamptonvWatfordPremier League · England | 0–2 | Premier League · England |
| 2017-08-26 | HuddersfieldvSouthamptonPremier League · England | 0–0 | Premier League · England |
| 2017-08-19 | SouthamptonvWest HamPremier League · England | 3–2 | Premier League · England |
| 2017-08-12 | SouthamptonvSwanseaPremier League · England | 0–0 | Premier League · England |
| 2017-05-21 | SouthamptonvStokePremier League · England | 0–1 | Premier League · England |
| 2017-05-17 | SouthamptonvMan UnitedPremier League · England | 0–0 | Premier League · England |
| 2017-05-13 | MiddlesbroughvSouthamptonPremier League · England | 1–2 | Premier League · England |
| 2017-05-10 | SouthamptonvArsenalPremier League · England | 0–2 | Premier League · England |
| 2017-05-07 | LiverpoolvSouthamptonPremier League · England | 0–0 | Premier League · England |
| 2017-04-29 | SouthamptonvHullPremier League · England | 0–0 | Premier League · England |
| 2017-04-25 | ChelseavSouthamptonPremier League · England | 4–2 | Premier League · England |
| 2017-04-15 | SouthamptonvMan CityPremier League · England | 0–3 | Premier League · England |
| 2017-04-08 | West BromvSouthamptonPremier League · England | 0–1 | Premier League · England |
| 2017-04-05 | SouthamptonvCrystal PalacePremier League · England | 3–1 | Premier League · England |
| 2017-04-01 | SouthamptonvBournemouthPremier League · England | 0–0 | Premier League · England |
| 2017-03-19 | TottenhamvSouthamptonPremier League · England | 2–1 | Premier League · England |
| 2017-03-04 | WatfordvSouthamptonPremier League · England | 3–4 | Premier League · England |
| 2017-02-11 | SunderlandvSouthamptonPremier League · England | 0–4 | Premier League · England |
| 2017-02-04 | SouthamptonvWest HamPremier League · England | 1–3 | Premier League · England |
| 2017-01-31 | SwanseavSouthamptonPremier League · England | 2–1 | Premier League · England |
| 2017-01-22 | SouthamptonvLeicesterPremier League · England | 3–0 | Premier League · England |
| 2017-01-14 | BurnleyvSouthamptonPremier League · England | 1–0 | Premier League · England |
| 2017-01-02 | EvertonvSouthamptonPremier League · England | 3–0 | Premier League · England |
| 2016-12-31 | SouthamptonvWest BromPremier League · England | 1–2 | Premier League · England |
| 2016-12-28 | SouthamptonvTottenhamPremier League · England | 1–4 | Premier League · England |
| 2016-12-18 | BournemouthvSouthamptonPremier League · England | 1–3 | Premier League · England |
| 2016-12-14 | StokevSouthamptonPremier League · England | 0–0 | Premier League · England |
| 2016-12-11 | SouthamptonvMiddlesbroughPremier League · England | 1–0 | Premier League · England |
| 2016-12-03 | Crystal PalacevSouthamptonPremier League · England | 3–0 | Premier League · England |
| 2016-11-27 | SouthamptonvEvertonPremier League · England | 1–0 | Premier League · England |
| 2016-11-19 | SouthamptonvLiverpoolPremier League · England | 0–0 | Premier League · England |
| 2016-11-06 | HullvSouthamptonPremier League · England | 2–1 | Premier League · England |
| 2016-10-30 | SouthamptonvChelseaPremier League · England | 0–2 | Premier League · England |
| 2016-10-23 | Man CityvSouthamptonPremier League · England | 1–1 | Premier League · England |
| 2016-10-16 | SouthamptonvBurnleyPremier League · England | 3–1 | Premier League · England |
| 2016-10-02 | LeicestervSouthamptonPremier League · England | 0–0 | Premier League · England |
| 2016-09-25 | West HamvSouthamptonPremier League · England | 0–3 | Premier League · England |
| 2016-09-18 | SouthamptonvSwanseaPremier League · England | 1–0 | Premier League · England |