| 2022-08-13 | BrightonvNewcastlePremier League · England | 0–0 | Premier League · England |
| 2022-08-07 | Man UnitedvBrightonPremier League · England | 1–2 | Premier League · England |
| 2022-05-22 | BrightonvWest HamPremier League · England | 3–1 | Premier League · England |
| 2022-05-15 | LeedsvBrightonPremier League · England | 1–1 | Premier League · England |
| 2022-05-07 | BrightonvMan UnitedPremier League · England | 4–0 | Premier League · England |
| 2022-04-30 | WolvesvBrightonPremier League · England | 0–3 | Premier League · England |
| 2022-04-24 | BrightonvSouthamptonPremier League · England | 2–2 | Premier League · England |
| 2022-04-20 | Man CityvBrightonPremier League · England | 3–0 | Premier League · England |
| 2022-04-16 | TottenhamvBrightonPremier League · England | 0–1 | Premier League · England |
| 2022-04-09 | ArsenalvBrightonPremier League · England | 1–2 | Premier League · England |
| 2022-04-02 | BrightonvNorwichPremier League · England | 0–0 | Premier League · England |
| 2022-03-16 | BrightonvTottenhamPremier League · England | 0–2 | Premier League · England |
| 2022-03-12 | BrightonvLiverpoolPremier League · England | 0–2 | Premier League · England |
| 2022-03-05 | NewcastlevBrightonPremier League · England | 2–1 | Premier League · England |
| 2022-02-26 | BrightonvAston VillaPremier League · England | 0–2 | Premier League · England |
| 2022-02-19 | BrightonvBurnleyPremier League · England | 0–3 | Premier League · England |
| 2022-02-15 | Man UnitedvBrightonPremier League · England | 2–0 | Premier League · England |
| 2022-02-12 | WatfordvBrightonPremier League · England | 0–2 | Premier League · England |
| 2022-01-23 | LeicestervBrightonPremier League · England | 1–1 | Premier League · England |
| 2022-01-18 | BrightonvChelseaPremier League · England | 1–1 | Premier League · England |
| 2022-01-14 | BrightonvCrystal PalacePremier League · England | 1–1 | Premier League · England |
| 2022-01-02 | EvertonvBrightonPremier League · England | 2–3 | Premier League · England |
| 2021-12-29 | ChelseavBrightonPremier League · England | 1–1 | Premier League · England |
| 2021-12-26 | BrightonvBrentfordPremier League · England | 2–0 | Premier League · England |
| 2021-12-15 | BrightonvWolvesPremier League · England | 0–1 | Premier League · England |
| 2021-12-04 | SouthamptonvBrightonPremier League · England | 1–1 | Premier League · England |
| 2021-12-01 | West HamvBrightonPremier League · England | 1–1 | Premier League · England |
| 2021-11-27 | BrightonvLeedsPremier League · England | 0–0 | Premier League · England |
| 2021-11-20 | Aston VillavBrightonPremier League · England | 2–0 | Premier League · England |
| 2021-11-06 | BrightonvNewcastlePremier League · England | 1–1 | Premier League · England |
| 2021-10-30 | LiverpoolvBrightonPremier League · England | 2–2 | Premier League · England |
| 2021-10-23 | BrightonvMan CityPremier League · England | 1–4 | Premier League · England |
| 2021-10-16 | NorwichvBrightonPremier League · England | 0–0 | Premier League · England |
| 2021-10-02 | BrightonvArsenalPremier League · England | 0–0 | Premier League · England |
| 2021-09-27 | Crystal PalacevBrightonPremier League · England | 1–1 | Premier League · England |
| 2021-09-19 | BrightonvLeicesterPremier League · England | 2–1 | Premier League · England |
| 2021-09-11 | BrentfordvBrightonPremier League · England | 0–1 | Premier League · England |
| 2021-08-28 | BrightonvEvertonPremier League · England | 0–2 | Premier League · England |
| 2021-08-21 | BrightonvWatfordPremier League · England | 2–0 | Premier League · England |
| 2021-08-14 | BurnleyvBrightonPremier League · England | 1–2 | Premier League · England |
| 2021-05-23 | ArsenalvBrightonPremier League · England | 2–0 | Premier League · England |
| 2021-05-18 | BrightonvMan CityPremier League · England | 3–2 | Premier League · England |
| 2021-05-15 | BrightonvWest HamPremier League · England | 1–1 | Premier League · England |
| 2021-05-09 | WolvesvBrightonPremier League · England | 2–1 | Premier League · England |
| 2021-05-01 | BrightonvLeedsPremier League · England | 2–0 | Premier League · England |
| 2021-04-24 | Sheffield UnitedvBrightonPremier League · England | 1–0 | Premier League · England |
| 2021-04-20 | ChelseavBrightonPremier League · England | 0–0 | Premier League · England |
| 2021-04-12 | BrightonvEvertonPremier League · England | 0–0 | Premier League · England |
| 2021-04-04 | Man UnitedvBrightonPremier League · England | 2–1 | Premier League · England |
| 2021-03-20 | BrightonvNewcastlePremier League · England | 3–0 | Premier League · England |