| 2022-11-12 | KarlsruhevSt Pauli2. Bundesliga · Germany | 4–4 | 2. Bundesliga · Germany |
| 2022-11-08 | KaiserslauternvKarlsruhe2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2022-11-05 | KarlsruhevHolstein Kiel2. Bundesliga · Germany | 1–4 | 2. Bundesliga · Germany |
| 2022-10-30 | HannovervKarlsruhe2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2022-10-23 | KarlsruhevFortuna Dusseldorf2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2022-10-15 | KarlsruhevDarmstadt2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2022-10-07 | BielefeldvKarlsruhe2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2022-10-02 | KarlsruhevNurnberg2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2022-09-16 | BraunschweigvKarlsruhe2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2022-09-10 | KarlsruhevHeidenheim2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2022-09-03 | HamburgvKarlsruhe2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2022-08-27 | KarlsruhevHansa Rostock2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2022-08-20 | RegensburgvKarlsruhe2. Bundesliga · Germany | 0–6 | 2. Bundesliga · Germany |
| 2022-08-13 | KarlsruhevSandhausen2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2022-08-05 | Greuther FurthvKarlsruhe2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-07-24 | KarlsruhevMagdeburg2. Bundesliga · Germany | 2–3 | 2. Bundesliga · Germany |
| 2022-07-17 | PaderbornvKarlsruhe2. Bundesliga · Germany | 5–0 | 2. Bundesliga · Germany |
| 2022-05-15 | HeidenheimvKarlsruhe2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2022-05-08 | KarlsruhevDresden2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2022-04-29 | HannovervKarlsruhe2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2022-04-22 | KarlsruhevIngolstadt2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2022-04-16 | HamburgvKarlsruhe2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2022-04-10 | PaderbornvKarlsruhe2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2022-04-03 | KarlsruhevFortuna Dusseldorf2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2022-03-18 | Erzgebirge AuevKarlsruhe2. Bundesliga · Germany | 0–3 | 2. Bundesliga · Germany |
| 2022-03-13 | KarlsruhevRegensburg2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-03-05 | St PaulivKarlsruhe2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2022-02-26 | KarlsruhevSchalke 042. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-02-19 | Holstein KielvKarlsruhe2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2022-02-12 | KarlsruhevNurnberg2. Bundesliga · Germany | 4–1 | 2. Bundesliga · Germany |
| 2022-02-08 | KarlsruhevSandhausen2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2022-02-05 | Werder BremenvKarlsruhe2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2022-01-15 | DarmstadtvKarlsruhe2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |