| Date | Match | Score | |
|---|---|---|---|
| L | 2026-02-07 | Tigres UANL v Santos Laguna | 5–1 |
| L | 2025-08-31 | Santos Laguna v Tigres UANL | 0–1 |
| L | 2025-03-15 | Tigres UANL v Santos Laguna | 3–0 |
| L | 2024-07-21 | Santos Laguna v Tigres UANL | 0–3 |
| L | 2024-02-11 | Santos Laguna v Tigres UANL | 0–3 |
| L | 2023-08-31 | Tigres UANL v Santos Laguna | 3–2 |
| L | 2023-01-09 | Santos Laguna v Tigres UANL | 0–3 |
| L | 2022-08-15 | Tigres UANL v Santos Laguna | 2–0 |
| D | 2022-01-13 | Santos Laguna v Tigres UANL | 1–1 |
| L | 2021-11-29 | Tigres UANL v Santos Laguna | 1–0 |
| W | 2021-11-26 | Santos Laguna v Tigres UANL | 2–1 |
| D | 2021-08-08 | Tigres UANL v Santos Laguna | 1–1 |
| W | 2021-01-18 | Santos Laguna v Tigres UANL | 2–0 |
| L | 2020-09-13 | Tigres UANL v Santos Laguna | 2–0 |
| W | 2020-02-17 | Santos Laguna v Tigres UANL | 2–1 |
| L | 2019-10-06 | Tigres UANL v Santos Laguna | 4–0 |
| L | 2019-02-03 | Tigres UANL v Santos Laguna | 2–1 |
| W | 2018-08-20 | Santos Laguna v Tigres UANL | 3–1 |
| W | 2018-05-07 | Santos Laguna v Tigres UANL | 2–0 |
| L | 2018-05-04 | Tigres UANL v Santos Laguna | 2–0 |
| L | 2018-01-14 | Tigres UANL v Santos Laguna | 2–1 |
| D | 2017-07-31 | Santos Laguna v Tigres UANL | 1–1 |
| D | 2017-01-08 | Tigres UANL v Santos Laguna | 0–0 |
| D | 2016-07-18 | Santos Laguna v Tigres UANL | 0–0 |
| W | 2016-04-24 | Santos Laguna v Tigres UANL | 2–1 |
League meetings on record only — domestic cup and European ties are not yet in the archive, so this is the league ledger of the rivalry, not every match ever played. Results from PitchVAR's own football warehouse.