| Date | Match | Score | Competition | |
|---|---|---|---|---|
| L | 2023-01-28 | Tranmere v Leyton Orient | 1–0 | League Two |
| W | 2022-09-03 | Leyton Orient v Tranmere | 2–0 | League Two |
| L | 2022-05-07 | Leyton Orient v Tranmere | 0–1 | League Two |
| L | 2021-12-18 | Tranmere v Leyton Orient | 1–0 | League Two |
| L | 2021-02-27 | Leyton Orient v Tranmere | 1–3 | League Two |
| W | 2020-10-20 | Tranmere v Leyton Orient | 0–1 | League Two |
| D | 2018-02-10 | Leyton Orient v Tranmere | 1–1 | National League |
| L | 2017-10-04 | Tranmere v Leyton Orient | 2–1 | National League |
| W | 2014-04-26 | Leyton Orient v Tranmere | 2–0 | League One |
| W | 2013-10-19 | Tranmere v Leyton Orient | 0–4 | League One |
| W | 2013-02-09 | Leyton Orient v Tranmere | 2–1 | League One |
| L | 2012-08-18 | Tranmere v Leyton Orient | 3–1 | League One |
| L | 2012-03-10 | Tranmere v Leyton Orient | 2–0 | League One |
| L | 2011-08-13 | Leyton Orient v Tranmere | 0–1 | League One |
| L | 2011-04-30 | Leyton Orient v Tranmere | 0–3 | League One |
| W | 2010-12-11 | Tranmere v Leyton Orient | 1–2 | League One |
| L | 2010-02-20 | Tranmere v Leyton Orient | 2–1 | League One |
| W | 2009-11-21 | Leyton Orient v Tranmere | 2–1 | League One |
| D | 2009-02-07 | Tranmere v Leyton Orient | 0–0 | League One |
| L | 2008-10-18 | Leyton Orient v Tranmere | 0–1 | League One |
| D | 2008-02-09 | Tranmere v Leyton Orient | 1–1 | League One |
| W | 2008-01-08 | Leyton Orient v Tranmere | 3–0 | League One |
| W | 2007-02-24 | Leyton Orient v Tranmere | 3–1 | League One |
| L | 2006-09-02 | Tranmere v Leyton Orient | 3–0 | League One |
| Competition | P | Leyton Orient W | D | Tranmere W |
|---|---|---|---|---|
| League One | 16 | 7 | 2 | 7 |
| League Two | 6 | 2 | 0 | 4 |
| National League | 2 | 0 | 1 | 1 |
League meetings on record only — domestic cup and European ties are not yet in the archive, so this is the league ledger of the rivalry, not every match ever played. Results from PitchVAR's own football warehouse.