| Date | Match | Score | |
|---|---|---|---|
| W | 2026-03-14 | Guadalajara Chivas v Santos Laguna | 3–0 |
| L | 2025-08-11 | Santos Laguna v Guadalajara Chivas | 1–0 |
| W | 2025-01-12 | Guadalajara Chivas v Santos Laguna | 1–0 |
| W | 2024-11-06 | Santos Laguna v Guadalajara Chivas | 0–2 |
| D | 2024-01-14 | Guadalajara Chivas v Santos Laguna | 1–1 |
| L | 2023-08-27 | Santos Laguna v Guadalajara Chivas | 2–1 |
| W | 2023-03-05 | Guadalajara Chivas v Santos Laguna | 2–0 |
| D | 2022-07-17 | Santos Laguna v Guadalajara Chivas | 1–1 |
| W | 2022-03-06 | Guadalajara Chivas v Santos Laguna | 1–0 |
| D | 2021-08-16 | Santos Laguna v Guadalajara Chivas | 0–0 |
| D | 2021-04-04 | Guadalajara Chivas v Santos Laguna | 1–1 |
| L | 2020-08-03 | Santos Laguna v Guadalajara Chivas | 2–0 |
| L | 2019-07-22 | Santos Laguna v Guadalajara Chivas | 3–0 |
| L | 2019-01-28 | Santos Laguna v Guadalajara Chivas | 1–0 |
| L | 2018-08-13 | Guadalajara Chivas v Santos Laguna | 1–2 |
| L | 2018-02-11 | Guadalajara Chivas v Santos Laguna | 0–2 |
| D | 2017-08-24 | Santos Laguna v Guadalajara Chivas | 1–1 |
| D | 2017-02-05 | Guadalajara Chivas v Santos Laguna | 1–1 |
| W | 2016-08-15 | Santos Laguna v Guadalajara Chivas | 0–1 |
| W | 2016-05-07 | Santos Laguna v Guadalajara Chivas | 0–1 |
| L | 2015-11-22 | Guadalajara Chivas v Santos Laguna | 0–3 |
| L | 2015-05-25 | Guadalajara Chivas v Santos Laguna | 0–3 |
| D | 2015-05-22 | Santos Laguna v Guadalajara Chivas | 0–0 |
| L | 2015-02-07 | Santos Laguna v Guadalajara Chivas | 1–0 |
| L | 2014-08-17 | Guadalajara Chivas v Santos Laguna | 0–1 |
League meetings on record only — domestic cup and European ties are not yet in the archive, so this is the league ledger of the rivalry, not every match ever played. Results from PitchVAR's own football warehouse.