| Date | Match | Score | |
|---|---|---|---|
| W | 2026-02-22 | Club Leon v Santos Laguna | 2–1 |
| L | 2025-10-19 | Santos Laguna v Club Leon | 2–0 |
| L | 2025-03-09 | Santos Laguna v Club Leon | 2–1 |
| D | 2024-08-25 | Club Leon v Santos Laguna | 1–1 |
| W | 2024-01-27 | Club Leon v Santos Laguna | 3–2 |
| W | 2023-11-27 | Club Leon v Santos Laguna | 3–2 |
| W | 2023-10-09 | Santos Laguna v Club Leon | 0–2 |
| W | 2023-03-20 | Club Leon v Santos Laguna | 4–1 |
| L | 2022-08-19 | Santos Laguna v Club Leon | 2–1 |
| D | 2022-04-25 | Santos Laguna v Club Leon | 1–1 |
| D | 2021-08-22 | Club Leon v Santos Laguna | 1–1 |
| W | 2021-03-22 | Santos Laguna v Club Leon | 1–2 |
| W | 2020-11-03 | Club Leon v Santos Laguna | 2–1 |
| L | 2020-01-20 | Santos Laguna v Club Leon | 3–2 |
| D | 2019-08-29 | Club Leon v Santos Laguna | 2–2 |
| W | 2019-03-03 | Club Leon v Santos Laguna | 3–0 |
| L | 2018-09-16 | Santos Laguna v Club Leon | 3–0 |
| L | 2018-02-15 | Santos Laguna v Club Leon | 5–1 |
| L | 2017-08-27 | Club Leon v Santos Laguna | 1–2 |
| D | 2017-02-19 | Club Leon v Santos Laguna | 2–2 |
| L | 2016-08-29 | Santos Laguna v Club Leon | 1–0 |
| W | 2016-01-10 | Club Leon v Santos Laguna | 2–0 |
| W | 2015-07-26 | Santos Laguna v Club Leon | 1–3 |
| W | 2015-03-01 | Club Leon v Santos Laguna | 2–1 |
| L | 2014-09-13 | Santos Laguna v Club Leon | 2–0 |
League meetings on record only — domestic cup and European ties are not yet in the archive, so this is the league ledger of the rivalry, not every match ever played. Results from PitchVAR's own football warehouse.